Publication Type
Journal Article
Journal Name
Parasites and Vectors
Publication Date
12-1-2022
Abstract
An integrated approach to innovatively counter the transmission of various arthropod-borne diseases to humans would benefit from strategies that sustainably limit onward passage of infective life cycle stages of pathogens and parasites to the insect vectors and vice versa. Aiming to accelerate the impetus towards a disease-free world amid the challenges posed by climate change, discovery, mindful exploitation and integration of active natural products in design of pathogen transmission-blocking interventions is of high priority. Herein, we provide a review of natural compounds endowed with blockade potential against transmissible forms of human pathogens reported in the last 2 decades from 2000 to 2021. Finally, we propose various translational strategies that can exploit these pathogen transmission-blocking natural products into design of novel and sustainable disease control interventions. In summary, tapping these compounds will potentially aid in integrated combat mission to reduce disease transmission trends.
Keywords
Anti-infectives, Arthropod disease vectors, Disease control, Human pathogen transmission-blocking, Natural products
PubMed ID
36002857
Recommended Citation
Muema, J., Bargul, J., Obonyo, M., Njeru, S., Matoke-Muhia, D., & Mutunga, J. (2022). Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions. Parasites and Vectors, 15 (1) https://doi.org/10.1186/s13071-022-05367-8