Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)

Publication Type

Journal Article

Journal Name

Phytochemistry

Name of Author

Ruth A. Omole, Kenyatta University
Jeremiah Gathirwa, Kenya Medical Research Institute
Hosea Akala, Kenya Medical Research Institute
Hamisi M. Malebo, National Institute For Medical Research Tanzania
Alex K. Machocho, Kenyatta University
Ahmed Hassanali, Kenyatta University
Isaiah O. Ndiege, Kenyatta University

Publication Date

1-1-2014

Abstract

Two bisbenzylisoquinoline and one hasubanane alkaloids: (-)-pseudocurine (1), (-)-pseudoisocurine (2) and (-)-10-oxoaknadinine (3), were isolated from leaf extract of Stephania abyssinica, a plant used in traditional medicine in South Nyanza region of Kenya. They were characterized using 1D (1H, 13C and DEPT) and 2D (COSY, NOESY, HMQC and HMBC) NMR techniques. (-)-Pseudocurine (1) and (-)-pseudoisocurine (2) exhibited strong to moderate anti-plasmodial activity while (-)-10-oxoaknadinine (3) showed moderate to mild activity. © 2014 Elsevier Ltd. All rights reserved.

Keywords

(-)-10-oxoaknadinine anti-plasmodial activity, (-)-Pseudocurine and (-)-pseudoisocurine, Alkaloids, Bisbenzylisoquinoline, Hasubanane, Menispermerceae, Stephania abyssinica

PubMed ID

24735823

Recommended Citation

Omole, R., Gathirwa, J., Akala, H., Malebo, H., Machocho, A., Hassanali, A., & Ndiege, I. (2014). Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae). Phytochemistry, 103, 123-128. https://doi.org/10.1016/j.phytochem.2014.03.026