Publication Type
Journal Article
Journal Name
Beilstein Journal of Organic Chemistry
Publication Date
2-27-2013
Abstract
The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids, namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin- 7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae. © 2013 Samita et al; licensee Beilstein-Institut.
Keywords
Alkaloids, Larvicidal activity, Zanthoxylum paracanthum
Recommended Citation
Samita, F., Sandjo, L., Ndiege, I., Hassanali, A., & Lwande, W. (2013). Zanthoxoaporphines A-C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae). Beilstein Journal of Organic Chemistry, 9, 447-452. https://doi.org/10.3762/bjoc.9.47