Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development

Publication Type

Journal Article

Journal Name

Phytochemistry

Name of Author

Mary L. Hamilton, Rothamsted Research
Serge P. Kuate, International Centre of Insect Physiology and Ecology Nairobi
Melissa Brazier-Hicks, University of York
John C. Caulfield, Rothamsted Research
Ruth Rose, School of Biological and Chemical Sciences Queen Mary University of London
Robert Edwards, University of York
Baldwyn Torto, International Centre of Insect Physiology and Ecology Nairobi
John A. Pickett, Rothamsted Research
Antony M. Hooper, Rothamsted Research

Publication Date

12-1-2012

Abstract

Isoschaftoside, an allelopathic di-C-glycosylflavone from Desmodium spp. root exudates, is biosynthesised through sequential glucosylation and arabinosylation of 2-hydroxynaringenin with UDP-glucose and UDP-arabinose. Complete conversion to the flavone requires chemical dehydration implying a dehydratase enzyme has a role in vivo to complete the biosynthesis. The C-glucosyltransferase has been partially characterised and its activity demonstrated in highly purified fractions. © 2012 Elsevier Ltd. All rights reserved.

Keywords

Biosynthesis, C-Glycosyltransferase, Desmodium intortum, Desmodium uncinatum, Di-C-glycosylflavone, Isoschaftoside

PubMed ID

22959223

Recommended Citation

Hamilton, M., Kuate, S., Brazier-Hicks, M., Caulfield, J., Rose, R., Edwards, R., Torto, B., Pickett, J., & Hooper, A. (2012). Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. Phytochemistry, 84, 169-176. https://doi.org/10.1016/j.phytochem.2012.08.005