Publication Type
Journal Article
Journal Name
Phytochemistry
Publication Date
7-1-2009
Abstract
The nor-halimane diterpenoid tessmannic acid and its methyl, 2-methylisopropyl and 1-methylbutyl esters, the unusual isocoumarins 8-hydroxy-6-methoxy-3-pentylisocoumarin and 7-chloro-8-hydroxy-6-methoxy-3-pentylisocoumarin, and 5-pentyl-3-methoxy-N-butylaniline were isolated from the stem and root bark extracts of Tessmannia densiflora Harms (Caesalpiniaceae) that showed mosquito larvicidal activity. The structures were determined on interpretation of spectroscopic data. Tessmannic acid and its methyl ester exhibited antibacterial and antifungal activity. The compounds also caused high larvae and adult Anopheles gambiae mosquitoe mortality effects, and stronger mosquito repellency than that shown by the standard repellent DEET, hence indicating Tessmannia species to be potential sources of bioactive natural products. © 2009 Elsevier Ltd. All rights reserved.
Keywords
Antimicrobials, Caesalpiniaceae, Isocoumarins anti-mosquitoes, Nor-halimanoids, Tessmannia densiflora
PubMed ID
19699496
Recommended Citation
Kihampa, C., Nkunya, M., Joseph, C., Magesa, S., Hassanali, A., Heydenreich, M., & Kleinpeter, E. (2009). Anti-mosquito and antimicrobial nor-halimanoids, isocoumarins and an anilinoid from Tessmannia densiflora. Phytochemistry, 70 (10), 1233-1238. https://doi.org/10.1016/j.phytochem.2009.07.024