Diversity of lepidopteran stem borers on monocotyledonous plants in eastern Africa and the islands of Madagascar and Zanzibar revisited
Publication Type
Journal Article
Journal Name
Science
Publication Date
8-23-2019
Abstract
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments.We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first highresolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
PubMed ID
31439762
Recommended Citation
Howick, V., Russell, A., Andrews, T., Heaton, H., Reid, A., Natarajan, K., Butungi, H., Metcalf, T., Verzier, L., Rayner, J., Berriman, M., Herren, J., Billker, O., Hemberg, M., Talman, A., & Lawniczak, M. (2019). Diversity of lepidopteran stem borers on monocotyledonous plants in eastern Africa and the islands of Madagascar and Zanzibar revisited. Science, 365 (6455) https://doi.org/10.1126/science.aaw2619