2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies

Publication Type

Journal Article

Journal Name

Bulletin of the Chemical Society of Ethiopia

Publication Date

6-1-2005

Abstract

2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD 50 22 μg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD50 10, 9, 4.8, 1.2 μg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4- methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 μg/mL) as 1. © 2005 Chemical Society of Ethiopia.

Keywords

2-Benzyloxybenzaldehyde, 2-Hdroxybenzaldehyde, 2-Hydroxy-4-methoxybenzaldehyde, Benzylphenyl ether Anopheles gambiae, Larvicides, Structure-activity relationships

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