Plasmodium falciparum transmission blocking immunity in three areas with perennial or seasonal endemicity and different levels of transmission
Publication Type
Journal Article
Journal Name
American Journal of Tropical Medicine and Hygiene
Publication Date
1-1-2005
Abstract
Plasmodium falciparum transmission blocking immunity (TBI) was investigated in 3 different endemic areas. Reared Anopheles gambiae s.s. were experimentally infected with the blood of gametocyte carriers, either in the presence of autologous plasma (OWN) or after replacement of the OWN plasma with a nonimmune serum of AB blood group (control). Transmission reduction was defined by a lower level of mosquito infection in the OWN batch compared with the control. After controlling for the effect of gametocytemia, the proportion of "transmission reducers" was lower in the town of Yaounde in Cameroon (UC), (14%, N = 75) than in the two rural areas of South Cameroon (RC) (29%, N = 31) and Sénégal (RS) (44%, N = 32). The contribution of TBI relative to the total inhibition of the parasite development (including human, parasite, and mosquito factors) was higher in RS (49.6%) than in RC (12.6%) and UC (9.5%). Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
PubMed ID
16354818
Recommended Citation
Boudin, C., Diop, A., Gaye, A., Gadiaga, L., Gouagna, C., Safeukui, I., & Bonnet, S. (2005). Plasmodium falciparum transmission blocking immunity in three areas with perennial or seasonal endemicity and different levels of transmission. American Journal of Tropical Medicine and Hygiene, 73 (6), 1090-1095. https://doi.org/10.4269/ajtmh.2005.73.1090