Publication Type

Journal Article

Journal Name

Phytochemistry

Publication Date

10-1-2004

Abstract

Five mosquito repellents have been identified from the essential oils of 6 plants growing in Kenya. These include (S)-(-)-cis-perillyl alcohol, (S)-(-)-cis-verbenol, (S)-(-)-cis-carveol, (S)-(-)-perillaldehyde, caryophyllene oxide and (S)-(-)-cis-perillyl alcohol. (S)-(-)-cis-perillyl alcohol and (S)-(-)-cis-verbenol were the most potent. Essential oils of six plants growing in Kenya were screened for repellent activities against Anopheles gambiae sensu stricto. The oils of Conyza newii (Compositeae) and Plectranthus marrubioides (Labiateae) were the most repellent (RD 50 = 8.9 × 10 -5 mg cm -2, 95% CI) followed by Lippia javanica (Verbenaceae), Lippia ukambensis (Verbenaceae), Tetradenia riparia, (Iboza multiflora) (Labiateae) and Tarchonanthus camphoratus (Compositeae). Eight constituents of the different oils (perillyl alcohol, cis-verbenol, cis-carveol, geraniol, citronellal, perillaldehyde, caryophyllene oxide and a sesquiterpene alcohol) exhibited relatively high repellency. Four synthetic blends of the major components (present in ≥1.5%) of the essential oils were found to exhibit comparable repellent activity to the parent oils. © 2004 Elsevier Ltd. All rights reserved.

Keywords

Alcohols, Anopheles gambiae, Epoxides, Essential oils, Repellent plants, Terpenoids

PubMed ID

15474566

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