Publication Type
Journal Article
Journal Name
Phytochemistry
Publication Date
1-1-2003
Abstract
Five novel limonoids, 1-5, were isolated from the root bark of Turraea wakefieldii and were characterized as tecleaninoid derivatives. This is the first report of the natural occurrence of tecleanin-type limonoids with a five-membered-ring A-seco structure for which we propose the name neotecleanins. The relative stereochemical structures of compounds 1-5 were established on the basis of NMR spectroscopy. The absolute stereochemical structure of 5 was confirmed by X-ray diffraction methods. In mosquito larvicidal assays, compounds 1, 2 and 4 showed dose-dependent larvicidal activity against larvae of Anopheles gambiae s.s. © 2003 Elsevier Ltd. All rights reserved.
Keywords
Anopheles gambiae s.s, Larvicidal activity, Limonoids, Meliaceae, Neotecleanins, Tecleaninoids, Turraea wakefieldii
PubMed ID
14559274
Recommended Citation
Ndung'U, M., Hassanali, A., Hooper, A., Chhabra, S., Miller, T., Paul, R., & Torto, B. (2003). Ring A-seco mosquito larvicidal limonoids from Turraea wakefieldii. Phytochemistry, 64 (4), 817-823. https://doi.org/10.1016/j.phytochem.2003.08.020